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In the months since the novel coronavirus rose from a regional crisis to a global threat, drug makers large and small have scrambled to advance their best ideas for thwarting a pandemic.

Some are taking a cue from older antivirals. Some are tapping tried-and-true technologies, and others are pressing forward with futuristic approaches to human medicine.

Here’s a guide to some of the most talked-about efforts to treat or prevent coronavirus infection, with details on the science, history, and timeline for each endeavor. We’re looking at novel medicines, not repurposed drugs. (For more on some of the efforts to repurpose drugs, read this.) The below therapies and vaccines are sorted in order of how close they could be to approval, starting with a treatment in Phase 3 trials, followed by others in Phase 1 studies and then preclinical development. Approval, of course, would only come if they are proven safe and effective. 

Gilead Sciences
Approach: Treatment
Stage: Phase 3

Gilead’s remdesivir is being studied in five clinical trials around the world. In China, Gilead is recruiting about 1,000 patients diagnosed with the coronavirus to determine whether multiple doses of remdesivir can reverse the infection. The primary goals are reducing fever and helping patients get out of the hospital within two weeks. The drug, which previously failed in a study on Ebola virus, is administered intravenously. More on the drug here.

Ascletis Pharma
Approach: Treatment
Stage: Phase 1

Chinese drug maker Ascletis Pharma is testing a combination of antivirals, one approved for HIV and one approved for hepatitis C, that might treat coronavirus infection. Last month, the company enrolled 11 patients with coronavirus-caused pneumonia and administered a cocktail of danoprevir and ritonavir. All 11 were eventually discharged, according to Ascletis. The company hasn’t disclosed plans for a larger study.

Moderna Therapeutics
Approach: Vaccine
Stage: Phase 1

Moderna set a drug industry record with mRNA-1273, a vaccine candidate identified just 42 days after the novel coronavirus was sequenced. The company is working with the National Institutes of Health on a healthy-volunteer study that began earlier this month. If mRNA-1273 proves itself to be safe, Moderna will enroll hundreds more patients to determine whether the vaccine protects against infection. Moderna’s product is a synthetic strand of messenger RNA, or mRNA, designed to convince bodily cells to produce antibodies against the virus. The company, founded in 2010, is yet to win Food and Drug Administration approval for any of its mRNA medicines. More on the vaccine candidate here.

CanSino Biologics
Approach: Vaccine
Stage: Phase 1

CanSino Biologics, headquartered in Tianjin, is close to testing its novel coronavirus vaccine in a clinical trial in China. CanSino’s approach involves taking a snippet of coronavirus’ genetic code and entwining it with a harmless virus, thereby exposing healthy volunteers to the novel infection and spurring the production of antibodies. The company said this week that Chinese authorities approved its planned trial, which will begin as soon as possible. CanSino markets a vaccine for Ebola virus in China.

Arcturus Therapeutics
Approach: Vaccine
Stage: Preclinical

Arcturus Therapeutics is pressing forward with a vaccine that relies on engineering RNA. The company plans to take an RNA virus that has been edited to encode for proteins that will protect against infection and load it into a liquid nanoparticle. The resulting vaccine, being developed in partnership with Duke University, promises a better immune response at a lower dose than competing mRNA approaches, according to the company. The vaccine remains in preclinical development, and Arcturus has promised to start a human trial as quickly as possible.

BioNTech
Approach: Vaccine
Stage: Preclinical

Germany’s BioNTech is working on an mRNA vaccine for the novel coronavirus with plans to enter clinical testing in April. Like its competitors, the company uses strands of mRNA to spur the production of protective antibodies. Earlier this month, Shanghai’s Fosun Pharma signed a deal to market BioNTech’s vaccine in China if it’s eventually approved. Pfizer has agreed to co-develop the vaccine in the rest of the world.

CureVac
Approach: Vaccine
Stage: Preclinical

Like Moderna, CureVac uses man-made mRNA to spur the production of proteins. And, like Moderna, it got a grant from the nonprofit Coalition for Epidemic Preparedness Innovations to apply its technology to coronavirus. CureVac has said it expects to have a candidate ready for animal testing by April, aiming to start a clinical study this summer. The company is also working with CEPI on a mobile mRNA manufacturing technology, one that would theoretically allow health care workers to rapidly-produce vaccines to respond at the site of an outbreak.

Eli Lilly
Approach: Treatment
Stage: Preclinical

Eli Lilly has partnered with a Canadian firm called AbCellera to develop antibody treatments for coronavirus infection. Using a blood sample from a coronavirus survivor, AbCellera identified more than 500 antibodies that might protect against the virus. Now it’s working with Lilly to identify which are most potent. The two companies aim to have a treatment ready for human trials within the next four months.

GlaxoSmithKline
Approach: Vaccine
Stage: Preclinical

GlaxoSmithKline, one of the world’s largest vaccine manufacturers, is lending its technology to a Chinese biotech firm at work on a coronavirus vaccine. Under an agreement signed last month, GSK is providing its proprietary adjuvants — compounds that enhance the effectiveness of vaccines — to Clover Biopharmaceuticals, a privately held company based in Chengdu. Clover’s approach involves injecting proteins that spur an immune response, thereby priming the body to resist infection. GSK struck a similar deal with the University of Queensland in Australia, which is also working on a protein vaccine. The company has not said when it expects to advance either into human testing. GSK is also lending its scientific expertise to CEPI.

Inovio Pharmaceuticals
Approach: Vaccine
Stage: Preclinical

Inovio has spent the last four decades working to turn DNA into medicine, and the company believes its technology could quickly generate a vaccine for the novel coronavirus. Working with CEPI grant money, Inovio has come up with a DNA vaccine it believes can generate protective antibodies and keep patients from infection. The company has partnered with a Chinese manufacturer, Beijing Advaccine Biotechnology, and is working through preclinical development with a candidate called INO-4800. The company expects to progress into clinical trials in April and has promised to manufacture 1 million doses of its candidate this year.

Johnson & Johnson
Approach: Vaccine and treatment
Stage: Preclinical

Johnson & Johnson, which has in the past responded to outbreaks of the Ebola and Zika viruses, is taking a multipronged approach to the coronavirus. The company is in the early days of developing a vaccine that would introduce patients to a deactivated version of the virus, triggering an immune response without causing infection. Human trials could begin by November. At the same time, J&J is working with the federal Biomedical Advanced Research and Development Authority on potential treatments for patients who are already infected, a process that includes investigating whether any of its older medicines might work against the coronavirus.

Pfizer
Approach: Vaccine and treatment
Stage: Preclinical

Outside of its vaccine work with BioNTech, Pfizer has put out a five-point plan to address the outbreak, which includes making its technology, scientists, expertise, and manufacturing available to outside institutions. The company has also promised to create a rapid-response program to make it easier to respond to future pandemics.

Regeneron Pharmaceuticals
Approach: Treatment
Stage: Preclinical

Regeneron has grown into a $50 billion business based on its ability to craft human antibodies out of genetically engineered mice. Now it’s tapping that technology in hopes of treating coronavirus. The company immunized its proprietary antibody-generating mice with a harmless analog of the novel coronavirus, generating potential treatments for the infection. Regeneron plans to select the two most potent antibodies and advance the cocktail into human studies by early summer. The last time Regeneron embarked on this process, during the Ebola outbreak of 2015, it came up with an antibody cocktail that roughly doubled survival rates for treated patients. More on Regeneron’s treatment here.

Sanofi
Approach: Vaccine and treatment
Stage: Preclinical

Sanofi, which has successfully developed vaccines for yellow fever and diphtheria, is working with BARDA on an answer to the coronavirus. Sanofi’s approach involves taking some of the coronavirus’s DNA and mixing it with genetic material from a harmless virus, creating a chimera that can prime the immune system without making patients sick. Sanofi expects to have a vaccine candidate to test in the lab within six months and could be ready to test a vaccine in people within a year to 18 months. Approval would likely be at least three years away, the company said. Outside of vaccines, Sanofi and Regeneron have started a clinical trial to test whether Kevzara, an approved anti-inflammatory drug, can help with the symptoms of Covid-19.

Takeda
Approach: Treatment
Stage: Preclinical

Japanese pharma giant Takeda is at work on a treatment derived from the blood of people who have already been infected by the coronavirus. The company is drawing blood from coronavirus survivors, harvesting the plasma, and then isolating the protective antibodies that kept those patients alive. It’s not a new idea. Blood transfusions have been used to combat viral outbreaks since at least the Spanish Flu pandemic of 1918. But Takeda’s take on it could prove to be faster in development than other therapeutic approaches. According to the company, the therapy could be available to patients in 12 to 18 months.

Vir Biotechnology
Approach: Treatment
Stage: Preclinical

Vir Biotechnology, a company focused on infectious disease, has isolated antibodies from people who survived SARS, a viral relative of the novel coronavirus, and is working to determine whether they might treat the infection. Teaming up with Chinese pharma contractor WuXi Biologics, the San Francisco-based Vir is in the early stages of development and hasn’t specified when it expects to have products ready for human testing. The company has also aligned with Alnylam Pharmaceuticals to work on treatments that might halt viral replication by interfering with RNA signaling. Vir’s CEO, Biogen veteran George Scangos, is also coordinating the trade group BIO’s response to the coronavirus outbreak.

This article originally published at https://www.statnews.com/2020/03/19/an-updated-guide-to-the-coronavirus-drugs-and-vaccines-in-development/

Did you ever wonder what is it that makes toothpaste work? Why do they make it taste so good? Is fluoride safe for kids? Here at Fort York Dentist we want to help you get the answers to those and other questions you may have. We will provide the answers to a few of them here.

What Makes Toothpaste Work?

There are two main ingredients in toothpastes that make it do its job. The fluoride makes your teeth stronger to resist decay and promote good oral health. It actually helps to heal your teeth by filling the tiny cavities that are starting to form. There are also some mild abrasive material like silica or phosphate salt that help to scrub your teeth without actually scratching them. Ask one of the dental technicians at Fort York Dentist in Toronto and they will be happy to explain it to you in further detail.

What about Whitening Toothpastes?

Those commercials that say you can get beautiful whiter teeth by using a certain toothpaste are very tempting. But the problem with these kinds of toothpastes is that they use harsher abrasive additives that take away the stains. These abrasive additives actually scratches the teeth and can do real damage including sensitive teeth because the enamel being removed is what protects the teeth from sensitivity. Also, the scratches in the teeth can harbor bacteria which will cause gum disease and cavities.

How Does Sensitivity Toothpaste Work?

Those toothpastes that reduce sensitivity use potassium nitrate to calm the tooth’s nerves. The way they stop or reduce sensitivity in your teeth is by blocking the pathways in the teeth that attach to the nerves. Most patients say they actually get some relief of tooth sensitivity to cold and hot food and drinks, but they can take up to a month or more to start working. These are not harmful and there is no reason to suspect that they damage your teeth or gums, so using them is fine.

Why Does Toothpaste Taste so Good?

Well, if it did not taste good you would probably not use it like you should. And it would be very difficult to get your children to brush their teeth too. The sweet or minty flavors are safe for your teeth and are made with saccharine, that is sweet but does not cause tooth decay.

Is Fluoride Safe for Kids?

There is no real danger for children even if they sit and eat a whole tube of toothpaste with fluoride, but we do not suggest that of course. If the child is under five years old it is best to just put a small dot of toothpaste on their toothbrush and keep an eye on them while they brush. Otherwise it is perfectly safe and it is best for fighting cavities. If you need more information please call Fort York Dentist in Toronto at (647) 346-8888 or (647) 343-8300.

Did you know your child needs to see a dentist before his or her first birthday? It is best to bring them in approximately six months after their teeth start coming in. At Fort York Dentist in Toronto we believe in treating the whole family, and starting visits early helps to prevent fearing the dentist. And by bringing your child in before they have any dental problems you can help to prevent tooth decay which also helps to prevent their overall fear. No tooth decay means no scary dental procedures that will give your child a reason to fear the dentist. Our dental technicians are specially trained to put your child at ease and put you at ease too.

What Will Happen at the First Visit?

Of course your child will be too young to take care of their own teeth at this early age, so we will generally just be educating the parents. It is important for the parents to know how to care for their baby’s teeth until they are old enough to do it themselves. Getting the child used to this process will instill good dental habits and they will automatically know that proper dental care is important. Here are some of the things the dentist at Fort York Dentist will do at your first visit:

• Look at your baby’s teeth, jaw, bite, gums and tissue to check for any abnormalities or problems that need to be taken care of.
• Gently clean and polish teeth and remove plaque and tartar if needed.
• Take x-rays of your child’s mouth.
• Show you the best way of cleaning your baby’s teeth until he or she is old enough to do it themselves.
• Explain the best toothpaste and floss for caring for your child’s overall dental health.

When scheduling an appointment for your child at our clinic, be sure to let them know that it is your child’s first visit. No matter how old they are at their first visit the dentist needs to prepare for a special session with you as well as your child. The appointment should be set early in the day at a time when your child is more receptive to others and not ready for a nap. If your child is under three years old you will be sitting in the chair holding him or her during the appointment. In some cases, if the child seems okay with it, the dentist will ask if you want to sit in the waiting room during the visit. This can help your child build a good relationship with the dentist and it is also good when mom or dad seem like they are nervous and may make things stressful for everyone.

How Often Should We Visit the Dentist?

At least every six months you should see the dentist. Of course if there is any pain or swelling you should make an appointment with us at Fort York Dentist in Toronto right away. Call us at (647) 346-8888 or (647) 343-8300 and we will set you an appointment.

You may think that brushing your teeth two times a day and even using mouthwash is enough for good oral health. But what about flossing? No matter how fancy your toothbrush is or how much it cost you it is not going to be able to get all of the food particles and plaque from between your teeth. Plaque is the bacteria that builds in between your teeth and that causes tooth decay and other dental problems.

What Kind of Floss Should I Use?

There are many kinds of dental floss and everyone is different so you may have to try several to find what is best for you. Some floss is waxed or not waxed, they can have flavor or no flavor, and there are different size widths to facilitate various sized mouths. The wide floss is called dental tape and is especially good for those people with bridge work and the teeth are spaced wider. Each of them do a good job of cleaning away food and plaque. The floss with wax is much easier for individuals who have extra small spaces between their teeth. The floss with no wax lets you know that you are doing it right when the floss makes a squeaky noise. The dentist at Fort York Dentist in Toronto can look at your teeth and give you a suggestion on what kind may be good for your teeth. Our dental technicians can give you some free samples to take home and try. Everyone’s teeth are spaced differently so you may have to try a few before you find the right one for you.

How to Floss Effectively

1. To begin flossing you will need about 15 to 20 inches of floss. Wind them around your middle fingers on each hand until you only have a one or two inch section to use.
2. Hold the floss with your thumbs and move it up and down in between each tooth.
3. Wrap the floss around the bottom of the tooth and make certain you get beneath the gum line. Be careful not to harm the gum tissue.
4. Make sure that you use a new area of the floss for each tooth.
5. Using the same method as step one, remove the floss up and away from the tooth

You may think flossing is not that important, but if may save you a few trips to the dentist, and the pain and aggravation of getting gum disease. Although we do like to see you when you visit us at Fort York Dentist, we like our patients to be happy and healthy. So, on your next visit to our clinic make sure to ask about different kinds and brands and what to do if you have any problems such as pain or bleeding. Come in for a check-up and we will give you a demonstration. The number at Fort York Dentist in Toronto is (647) 346-8888 or (647) 343-8300.

There are almost 30 million people in the United States diagnosed with diabetes. This serious disease causes the body to not have enough or to reject insulin, so their blood glucose levels have to be checked often. But, besides checking their sugar, diabetics also have to take special care of their teeth. In fact, having high glucose levels can cause a dry mouth which is one of the most common causes of dental problems in adults. The dentists and dental technicians at Fort York Dentist in Toronto are trained in the care of those with diabetes and can help you understand the precautions you must take as a diabetic. Here are five important things you need to know about diabetes and dental health:

• Keep your blood sugar controlled.
• Brush your teeth and use dental floss daily.
• See a Toronto dental care provider (Fort York Dentist) regularly.
• Let us know if your dentures are hurting or not fitting right.
• Do not smoke. If you already smoke – quit. We can help you with that at Fort York Dentist, so just ask one of our dental technicians or the dentist.

Periodontal Disease

The risk for periodontal disease is increased if you have diabetes because your body is more susceptible to infection and less able to fight infections. The bacteria in your mouth can cause a big problem because it will hamper your body’s ability to manage blood sugar and having high blood sugar will cause less of an ability to control the bacteria, leading to a circle of cause and effect that will be hard to control. This is worse for those whose glucose levels are not controlled well. It is important to have healthy blood sugar levels, eat a well-balanced diet and practice good oral care. We can help you curb this problem before it starts, but you have to let the dentist know that you have diabetes.

Fungal Infections

There are certain types of fungus that naturally live in your mouth already and this does not cause any problems in healthy people who take care of their teeth. But, those with diabetes do not have good immune systems so they get fungal infections more than most people. One of these fungal infections is candidiasis (thrush), which causes sores on your tongue and mouth that can become ulcers. It also causes a sore tongue and some people have trouble swallowing. This happens more often in smokers and people with dentures. Be sure to tell your dentist at Fort York Dentist if you have any soreness of your tongue or painful sores in your mouth.

We Can Help

Taking care of your teeth can actually help regulate your glucose levels by helping to prevent infection. Our dentists here at Fort York can give you a thorough deep tooth cleaning, which has been reported to assist in maintaining good blood sugar levels. Fort York Dentist is one of the best dentist offices in Toronto and we want you to have a healthy smile and a healthy body, so call (647) 346-8888 or (647) 343-8300 to schedule an appointment today.

Do you or someone you know grind your teeth? This disorder is called Bruxism (tooth grinding) and it can be incredibly hard on your teeth and jaw, causing a lot of dental problems. Some of the most common reasons for Bruxism are stress, misaligned jaw, sleep apnea, and certain medications. If you grind your teeth often it can cause breakage, loosening, and even losing some teeth. Sometimes it can even be so bad as to grind them down to the gums and that can cause a whole other set of problems. This is a very serious problem that you should see a Toronto physician about and you should also visit us here at Fort York Dentist.

See Your Doctor First

When you have Bruxism you will sometimes grind your teeth in your sleep making it impossible to even know that you are doing it. In fact, the only way many people find out is if someone sleeping near them tells them. If you wake up with a headache often or with jaw pain you could possibly be grinding your teeth at night. It is best to see your Toronto physician first, to rule out any other medical issues that can be causing the Bruxism. Fort York Dentist can give you a referral to someone you should see if you do not have a physician.

Children and Bruxism

According to some studies, approximately 25 percent of children suffer from bruxism. That does not necessarily mean the child is stressed out, it could be a natural growth related reaction. Another reason children grind their teeth is because of ear pain or teething discomfort. Also, studies show that bruxism is hereditary but the kids who have it in adolescence most likely will outgrow it. If you think you have bruxism because you wake up with ear and jaw pain, you should call us and make an appointment to find out what is going on because bruxism is treatable.

How to Treat Bruxism

You may not realize there is an option for bruxism sufferers, but at Fort York Dentist we can fit you to a plastic mouth guard that will stop the damage to your teeth. You may still grind your teeth but the guard protects you from doing any harm. Also, some bruxism sufferers noted that they get relief from just sleeping in a different position or giving up caffeine or smoking at night.

Daytime Bruxism

It is much easier to control bruxism during the day because you can actually catch yourself doing it. The dentist at Fort York Dentist in Toronto can give you some tips and tricks to make it easier to handle, such as yoga or listening to music.

If you do not treat your bruxism you will probably end up needing a root canal, partials, or even dentures eventually. We do not want you to wait that long. Why be in pain all that time? Call Fort York Dentist in Toronto at (647) 346-8888 or (647) 343-8300 and set an appointment today.

 

We all start noticing tiny lines around our eyes and mouth that some people call “Laugh Lines” but some people do not think it is anything to laugh about. It is hard to see the changes in your face when you feel there is nothing you can do to stop or control it. Maybe you do not want to have surgery or it is too expensive. And who wants to pay a bunch of money to get all that painful work done? Instead you can just visit us at Angel Gloss Clinic in Toronto and we will get you all fixed up without going under the knife. As a matter of fact, we have several choices that can help you achieve the look you want.

What Are Dermal Fillers?

The first thing you may think you should try is Botox injections, but if you want to do more than just get rid of some wrinkles then dermal filler injections would work out perfectly for you. Dermal, or soft tissue, fillers are different because we inject them into the wrinkle in your face to fill out that area so there is no line anymore. Botox actually relaxes the muscles and does not have anything to do with filling the wrinkled area. Some of our patients at Angel Gloss opt to use both treatments, which work very well together. There are two different dermal fillers we use here at Angel Gloss, they are sugar gels and bio-stimulatory fillers.

Sugar Gels and Bio-Stimulatory Gels

A sugar gel is actually called hyaluronic acid gel and it is the number one choice by professionals in this field. The sugar gel is injected into each wrinkled area and fills the lines in by absorbing the face’s normal soft tissue fluids and expanding. A bio-stimulatory gel is a polymer that incites a small reaction when injected that causes the creation of collagen. This collagen expands to fill the wrinkled area. Both of these types of gels are natural and your body will accept them as just another part of your body. Our cosmetician at Angel Gloss Cosmetic Centre in the greater Toronto area will be happy to sit down and meet with you and give you more information.

Does It Hurt?

Before we start the injections we clean your face and then numb it with a special cream that will prevent any pain that may be felt during the injections. After that, the filler is injected into your skin which causes very little pain or discomfort, but you may be sore in that spot for a day or two.

How Long Does It Last?

These sessions are not going to last forever. You will have to come back to the Angel Gloss Clinic about two times per year. But, it is much more natural looking than getting surgery. We will not be happy until you are happy. So give us a call at (647) 728-2400.

That tattoo may have seemed like a great idea at the time, but what about 30 to 40 years from now? Or even just a few years from now when you graduate from college and want to get hired for that great job but cannot seem to get it because of the tattoos on your neck and up and down your arms. Approximately 25% of the American population have a tattoo of some kind. But, studies show that almost 50% of those with tattoos end up wanting them removed eventually. The Angel Gloss Clinic in Toronto can get rid of your tattoo with very little pain and no major side effects.

How Does Laser Tattoo Removal Work?

The laser tattoo removal works by dividing the colors of the ink under your skin with a high intensity laser light. The cosmetology technician will test your skin first to determine what intensity is best for your skin. After this the technician will place the end of the laser tool on the tattoo and use bursts of light to break up the tattoo. Then the ink particles are small enough for the body to absorb and be disposed of through the liver. Different colors require different settings of the laser light. For example, black tattoo ink is easier to remove because it absorbs the laser light better than lighter colors. Also, a professional tattoo is much harder to remove than a tattoo given to you by one of your friends or someone you found on Craigslist. That is because professionals use better equipment and professional grade ink. The technicians at Angel Gloss in Toronto are specifically trained in the art of laser tattoo removal and you are free to ask questions before, during, and after the process.

Does Laser Tattoo Removal Hurt?

Of course there is some pain involved in the laser tattoo removal process, but it is not usually bad enough to need any kind of anesthesia. It all depends on the size of the tattoo and where it is on your body. There are certain areas that are more sensitive than others such as your ankle and top of your foot, anywhere in the eye area, chest area, lips, your elbows, hands, spine, behind your ear and inside of your wrist. The technician at Angel Gloss Clinic can give you a test pulse with the laser to see how it feels and if you decide it is too painful they can give you a shot of lidocaine or use a lidocaine cream. The problem with the cream is that it only numbs the top layer of skin so you can still feel a bit of the laser pulse. In this case you can opt for the lidocaine shot, which will numb the second layer of skin. Also, the technician at our Toronto Angel Gloss clinic will use ice packs both before and after the procedure.

If you are thinking of getting a tattoo removed with laser treatment just give us a call and we can help you decide whether the process is right for you. You can reach us at (647) 728-2400.

There are basically four different types of face contouring that you can get done with dermal fillers at Angel Gloss in Toronto. There are many different dermal fillers such as Hyaluronic acid, Calcium Hydroxylapatite, Poly-L-lactic Acid, and Polymethylmethacrylate. At Angel Gloss we use certain kinds on different areas of the face. Here are the different procedures we can do for you:

Lip Augmentation

This is very popular in the Toronto area and is done by injecting hyaluronic acid into your lips to make them look fuller and contoured. Our technician at Angel Gloss will help you decide whether this procedure is right for you and will discuss with you how you want your lips to look. Not only can we fill your lips, but we can also remove lines from the sides of the mouth and smooth out the ridges between your nose and mouth. We put a pain relieving cream on your skin first to minimize discomfort. The results will last about six months because the Hyaluronic acid is a naturally metabolized fluid that will eventually be absorbed by the body. It is a safe procedure and will not affect your ability to eat, smile, talk, etc.

Chin & Cheek Augmentation

This procedure is done to give a more defined look to sunken cheeks or a receding chin, and decrease your wrinkles and dimples if desired. There are certain ways our technician at Angel Gloss Clinic in Toronto can contour your face the way you desire with dermal fillers. The type of filler used depends on the procedure being done. We rub a lidocaine cream on your skin before the injections to decrease any discomfort.

Non-Surgical Nose Job

At Angel Gloss we can perform a nose job without any surgery at all! We can use hyaluronic acid gel placed in strategic places around your nose to help with a nose that is crooked, too small, hooked or bumpy. We use a topical lidocaine cream on your skin before the injections to reduce any discomfort. Once the injections are done the technician will use a pressurized massage to get your nose in the shape you want.

Non-Surgical Face Lifting

If you do not want to get an expensive and painful surgery for a facelift we can do it at Angel Gloss Cosmetic Centre without surgery. We use several different types of fillers to perform each part of the facial procedure. First we will map out the areas of the face and what you would like done to each area. The problem areas usually mentioned are eyelids, jowls, cheeks, and lips, along with wrinkles and lines around the mouth and nose. Whatever the problem, we can fix it for you.

Set an Appointment

All of these procedures are safe and our technicians are thoroughly trained with years of experience. Call Angel Gloss today and set an appointment to come in and speak to one of our specialists. You can reach us at (647) 728-2400 to reserve your appointment today.

It seems that Botox is not just for getting rid of wrinkles anymore. At Angel Gloss Clinic of Toronto we can do many treatments with Botox; including migraine treatments, wrinkle treatments, masseter weakening, treating muscle spasms of the face, eyes, and neck, and now hyperhidrosis (excessive sweating) Botox injection treatments. If you have problems with excess sweating and have tried other treatments, such as certain medications and iontophoresis, you are a good candidate for sweating treatment with Botox at Angel Gloss Clinic in Toronto.

What is Botox for Excessive Sweating?

Botox is actually a toxin called botulinum toxin A mixed into a protein that blocks the nerves in the eccrine glands that create sweat. While it does not cure hyperhidrosis, it does reduce the production of sweat for about three to six months, with some patients reporting it has worked for over a year. The FDA has signed off on the treatment of excessive sweating under the arms as well as in the hands and feet. Angel Gloss Clinic is certified by the UK to treat patients with hyperhidrosis of the armpit, but to get treatment in your hands and feet you have to go to a hospital because it can be painful and the patient may need a general anesthetic. Botox actually prevents the chemicals that make the sweat glands active.

How Long Does Botox for Hyperhidrosis Last?

One Botox treatment done by our technicians at Angel Gloss Clinic will decrease the sweating under your arms by up to 90% and can last six months to even a year or more. You will start to notice the change within a few days. The treatments can be used for heavy sweating under your arms, in your hands and feet, and on your head and face. There is very little pain, but if you choose, you can have the technician use a numbing cream on your skin before the surgery.

Is Botox for Excessive Sweating Safe?

Botox for excessive sweating in any part of the body is perfectly safe as long as it is done by a trained professional like the technicians at the Angel Gloss Center in Toronto. Since beginning the use of Botox in 1989 millions of people have been treated for excessive sweating. More than 20 countries have begun using Botox for the treatment of hyperhidrosis. What’s more is that this procedure can relieve your symptoms as well as improve your day to day lifestyle. Excessive sweating can be a big problem for many and can hamper both personal and professional life.

Give us a Call Today

If you have a problem with excessive sweating and have already tried other treatments by your doctor you should give us a call at (647) 728-2400 and set an appointment. Our technicians at our Angel Gloss Clinic in Toronto can get together with you and see if this procedure will work in your case.

Many people have never heard of skin photo rejuvenation or know what it is. This rejuvenation process is also called IPL (intense pulsed light) because it uses intense pulsed light in certain areas to remove dark, decrease the size of your pores and can even remove wrinkles. This makes your skin look overall smoother and younger looking. At our Angel Gloss Clinic in Toronto the technician can explain the process to you and help you decide whether it is right for you or not.

Skin photo rejuvenation is done by sending a pulse of intense light that penetrates deep into the layers of your skin. The light is generated into heated power that is soaked up by the damaged areas of your skin such as age and sun spots, creases, and veins close to the top of the skin that is visible. The light actually encourages the creation of the body’s natural collagen to get rid of these areas you want removed. The procedure will reduce the size of your pores, wrinkles, and lines as well as getting rid of the dark spots.

What Are These Treatments Good For?

You can use skin photo rejuvenation for many problems. The most common uses are to lighten and get rid of age and sun spots, and blotches on the face, neck, chest and hands. Another way that skin rejuvenation is used is to lighten the blush of rosacea, which is a redness of the face from dilated blood vessels. The technicians at our Toronto based Angel Gloss Clinic can also control flushing if it is a constant problem for you. It removes the rosiness of the blood vessels and stimulates the collagen that decreases pores and helps dry up oily skin as well.

How Long Does Skin Photo Rejuvenation Work?

It may take a few treatments about four to six weeks apart to achieve the results you want, but after that it can last for years when done by Angel Gloss Clinic. Of course this depends on the magnitude of the problem, so if you have a lot of redness from rosacea or sun damage you may need up to five treatments, each about a month apart. Also, once you get the results you want it is up to you to take care of your skin and not get too much sun exposure. The better you take care of your skin the better it will look.

What Should I Expect?

First, a technician in our clinic will use a gel on your skin and they will give you eye protective glasses to wear. Then the light will be pulsed into the skin until they cover the area to be treated. It lasts approximately a half an hour and you can go back to work of whatever you want to do immediately, but try to cover your skin with sun protectant of SPF 30 or higher to block the sun. If you want to see if you are a good candidate for Skin Photo Rejuvenation give Angel Gloss Clinic a call at (647) 728-2400.

(Guest Post by piracetam.net)

Because of stress and other strenuous activities, there are some things that people cannot do well. For some, these are just physical activities but for others, it includes being forgetful or sometimes unable to concentrate well. This is the reason why people go for balanced diet and exercise with supplements so that they can really perform their tasks efficiently. In connection to this, one of the most sought and bought supplements because they are good memory enhancers, they can help in concentrating, and they can help in having a good mood all day. However, all medications have side effects and these are things that should be carefully considered because side effects can cause discomfort especially on the part of the user. Here are the side effects of nootropics that you should carefully consider.

The most commonly reported side effect of nootropics is headache. People believe that because nootropic is a drug designed to help the brain, when a person has a headache it is said that the brain cells are being awaken and are helped to function. So, it is better to know some therapeutic ways to get rid of this headache just like a massage and enough sleep. Moreover, there are nootropics that have choline which can help in reducing the tendencies of headache.

Aside from headache, people who take nootropic also feel too much tiredness and then insomnia. Insomnia is the inability to sleep right away usually late in the dawn. Nootropics can help a person in being alert all day because it is a stimulant. However, if this supplement is also taken later in the day, you can expect insomnia and too much tiredness due to inability and lack of sleep. The best thing to do is to take the nootropic early in the morning to ensure good sleep at night. You can also drink milk to help you have a good night sleep.

Lastly, people who are taking nootropics may feel nervousness and anxiety. People may feel their hearts are racing and feel that they are alert all day. People who are taking nootropics actually feel that they are in a good mood all throughout the day, and they are always alert. If this is the case, they can feel that some palpitations and sweating. So, it is very important to check the brand of nootropic first and if that brand is not working out for you, then you can choose another one. You may also want to try other effective relaxation techniques such as deep breathing or even paper bag technique.

Overall, nootropics are good drugs especially in enhancing your brain functions. However, just like any drug, there are potential side effects that may occur. It is best to choose the right brand for you and also make it clear with your doctor on the right dosage of the drug. If you do not have the right dosage and the right time of taking, then you can expect that the side effects are really going to be a problem.

Useful Reference Links:

Potential Nootropic Side Effects: Are They Dangerous To Take?
Dangerous Nootropics Side Effects
The Dark Side of Smart Drugs
Nootropics | Do They Work? Side Effects?
Potential Dangers Of Nootropics: What To Consider Before Using Smart Drugs

(Guest Post by piracetam.net)

These days, people are very much concerned with their overall health. Why not? Diet and stress have taken over and have brought so many diseases which include cancer and so many more. This is the reason is why being health conscious is very important. People have eaten the right food and have started exercising and have also taken the right health supplements.

So, if your concern is about being forgetful especially at work and in school, then taking nootropics is the best thing to do. This type of supplements can actually help in enhancing brain function and so much more. If you are not convinced enough, here are the advantages of taking nootropics.

First, this supplement can help in concentrating especially in work and also in school. A lot of students and workers who have bought nootropics have testified that they can concentrate more and they have better results especially at home and in school. They have performed their tasks well and students have better scores especially in their exams.

Second, nootropics can actually help in the proper improvement of your brain. It is believed that nootropics can actually help in the proper oxygenation of the brain. Moreover, it can also help in the proper performance of the brain cells. People who have taken nootropics are believed to have lesser chances of having brain diseases which include Alzheimer’s disease.

Moreover, students who want to learn more can also take this supplement. People who have taken this supplement are believed to have become better, especially in learning out a new skill. So whether you are a student or you are a worker who is working on getting a job promotion, this supplement is definitely for you.

Fourth, if you want to look and stay young, then definitely nootropics is the right supplement for you. It is believed that this type of supplement can help in slowing down the signs of aging just like the wrinkles in the face; it slows down the poor vision, and so many more. So, with a better brain and stress-free brain, you can surely have a better life.

Also, people who want to remain alert to continue their tasks should take nootropics. If you have enough oxygen in your brain you will surely remain focused and alert. If these things will happen then of course, you can perform your task in a daily basis.

Lastly, nootropics have the bigger chances of contributing to less stress and therefore lesser chances of getting depressed. People who are depressed tend to have suicidal thoughts and they feel sad in most of the day. People who are less stress are in better mood and are better in performing their tasks.

In summary, when you want to have a better life, it is best to take nootropics. This supplement can actually help in having good mood, lesser stress, and a better life. Aside from taking supplements, it is important to eat a balanced diet and have daily exercise as well.

Useful Reference Links:

Top Reasons Why You Should Use Nootropics – Smart Drug Guide
Why Should You Use Nootropic Supplements for your Brain?
5 Reasons Successful People Are Using Smart Drugs
7 Reasons Everyone is Using Smart Drugs
The Top 5 Benefits of Nootropics